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  • Ponvory®
Back to Treatment Guide

Ponvory®

ponesimod

Quick Facts

Ponvory® reduces the number of white blood cells, immune cells called lymphocytes, thereby reducing nerve damage.

Tablet taken orally.

Once per day.

Relapsing forms of multiple sclerosis in adults, including clinically isolated syndrome, relapsing-remitting MS, and active secondary-progressive MS

Potential Benefit:

Compared to an active comparator over a 108-week the OPTIMUM study:

  • 30.5% lower annual relapse rate
  • 59% reduction in new gadolinium-enhancing (GdE) T1 lesions and 56% reduction in the number of new or enlarging T2 lesions
  • Worsening disability was prevented for most people

Common Potential Side Effects

Upper respiratory tract infections, elevated liver enzymes, high blood pressure

Prescription Assistance:

Wellness Companion >

For assistance finding additional resources that might help cover the costs of your prescription, contact MSAA.

Hear from the Expert
Regina Berkovich, MD, PhD
MS Neurology
Regina Berkovich, MD, PhD
“Importance of involving patients in their treatment decision cannot be overstated. It is really the decision of two specialists.”

DRUGMAKER

Janssen

HOW Ponvory® WORKS

Ponvory® is thought to trap the number of white blood cells (immune cells) called ‘lymphocytes’ in the lymph nodes, thereby reducing the number of white blood cells that get sent to the nervous system. This helps helps reduce nerve damage.

FDA-Approved

Ponvory® was FDA approved in 2021 to treat relapsing forms of MS, including clinically isolated syndrome, relapsing-remitting disease, and active secondary-progressive disease, in adults.

Potential Side Effects

Upper respiratory tract infections, elevated liver enzymes, and high blood pressure. Adverse effects can include more serious infections and a slowed heart rate (bradycardia or bradyarrhythmia), macular edema (swelling behind the eye), as well as skin cancer.

OTHER KEY INFORMATION

First-dose monitoring is required for people with certain cardiac conditions. Subsequent check-ups at a frequency determined by your healthcare provider.

Testing completed prior to starting Ponvory® includes: Pre-testing is required, including CBC, liver function studies, cardiac evaluation to include EKG, ophthalmology evaluation, and varicella testing.
CBC and liver function studies should be repeated periodically. (How frequently they should be repeated is not specified but should be done at least yearly.) Ophthalmology evaluations may be repeated as clinically indicated.

When taking Ponvory, please note there is a titration period (starting at a smaller dose and increasing over successive weeks).

Patient advocates talk about
their treatment experience

  • Kristie Salerno Kent
    MS Advocate, Patient Advocacy Consultant
    Kristie Salerno Kent
    “I have had situations where treatments aren’t approved at first. My doctors, nurses, they go actually go to bat for me and made it happen.”
  • Azure Antoinette
    MS Advocate
    Azure Antoinette
    “I wish would have had access or agency to get seen sooner and to treat this sooner.”
  • Damian Washington
    MS Advocate
    Damian Washington
    “Nobody’s going to be looking out for your best interests better than you.”
  • Cathy Chester
    MS Advocate
    Cathy Chester
    “I think it’s really important to talk about how to age with this illness.”
  • Lauren Hutton-Work
    MS Advocate
    Lauren Hutton-Work
    “Just because you have this disease does not mean that your work life should be awkward or uncomfortable.”
  • Chernise Joseph
    MS Advocate
    Chernise Joseph
    “My first neurologist was a frontline neurologist, he wasn’t an MS specialist.”
  • Julian Gamboa
    MS Advocate
    Julian Gamboa
    “If you’re newly diagnosed with multiple sclerosis remember it’s always okay to get a second opinion.”
  • Sam and Lauren Alcorn
    MS Advocates
    Sam and Lauren Alcorn
    “Our future is uncertain and we have to enjoy each other and love each other in the present.”
  • Shawn Feliciano
    MS Advocate
    Shawn Feliciano
    “I want to know what medications might work best for someone who’s Hispanic.”
  • Darlene Feigen
    MS Advocate
    Darlene Feigen
    “The sooner you get on a therapy the better it is in the long run.”
  • Birgit Bauer
    MS Advocate
    Birgit Bauer
    “At the end of the appointment you should have an answer to the most important questions.”
  • Ellen Tutton
    MS Advocate
    Ellen Tutton
    “I looked up all the different disease modifying therapies and compared them to my lifestyle.”
  • Victoria Marie Reese
    MS Advocate
    Victoria Marie Reese
    “I’m trying to show my daughter that taking care of yourself is cool.”
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Last modified: Aug 4, 2022

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