The 10 FDA-Approved Long-Term Treatments for MS

The following list includes the 10 disease-modifying therapies (DMTs) that are FDA-approved (at the time of this booklet’s printing) for the long-term treatment of MS.

Given via self-injection:

  • Avonex® (interferon beta-1a), given weekly
  • Betaseron® (interferon beta-1b), given every other day
  • Copaxone® (glatiramer acetate), given daily or three-times weekly
  • Extavia® (interferon beta-1b), given every other day
  • Rebif® (interferon beta-1a), given three-times weekly

Given via intravenous (IV) infusion:

  • Novantrone® (mitoxantrone), given every three months, although seldom prescribed due to serious health risks
  • Tysabri® (natalizumab), given every four weeks

Taken orally:

  • Aubagio® (teriflunomide), taken daily
  • Gilenya® (fingolimod), taken daily
  • Tecfidera™ (dimethyl fumarate or DMF), taken twice daily

At the time of printing, the 10 drugs listed above were the only ones approved by the FDA for the long-term treatment of MS. However, several other drugs are under FDA review. These include: Plegridy™ (PEGylated interferon beta-1a), which is self-injected every two weeks; one or more generic versions of Copaxone® (listed above); and Lemtrada® (alemtuzumab), given via IV in annual courses. For more information on long-term treatments for MS and how to select the treatment that is right for you, please see MSAA’s S.E.A.R.C.H.™ program at

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