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87 Hueber W, et al. “Effects of AIN457, a fully human antibody to interleukin-17A, on psoriasis, rheumatoid arthritis, and uveitis.” Sci Transl Med. 2(52), 52ra72 (2010).

88 ClinicalTrials.gov Identifier: NCT01051817

89 Rudick, et al. Presented at ECTRIMS 2013

90 Yadav V, et al. “Recombinant T-Cell Receptor Ligand (RTL) for Treatment of Multiple Sclerosis: A Double-Blind, Placebo-Controlled, Phase 1, Dose-Escalation Study.” Autoimmune Dis. 2012;2012:954739. Epub 2012 Apr 5.

91 Miller DH, et al. “Firategrast for relapsing remitting multiple sclerosis: a phase 2, randomised, double-blind, placebo-controlled trial.” Lancet Neurol. 2012 Feb;11(2):131-9. doi: 10.1016/S1474-4422(11)70299-X. Epub 2012 Jan 5.

92 CD49d antisense drug ATL1102 reduces disease activity in patients with relapsing-remitting MS. Limmroth at al. Neurology November 11, 2014 vol. 83 no. 20 1780-1788.

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96 Nash et al, JAMA Neurology, published online Dec 29 2014.

97 Burman J, et al. ECTRIMS 2013 [Poster 1017]

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99 ClinicalTrials.gov Identifier: NCT01933802

100 Ross C, Multiple Sclerosis 2014;20(1 Suppl):509-10.